急性人类肾移植排斥反应中前列环素合成增强。
Enhanced prostacyclin synthesis in acute human kidney transplant rejection.
作者信息
Leithner C, Sinzinger H, Silberbauer K, Wolf A, Stummvoll H K, Pinggera W
出版信息
Proc Eur Dial Transplant Assoc. 1980;17:424-8.
In acute and chronic kidney transplant rejection renal cortical and medullary tissue samples were examined for their prostacyclin (PGI2) generation by bioassay and compared with normal tissue. In acute rejection PGI2 formation was significantly enhanced, particularly in the cortex. In chronic rejection the PGI2 formation was comparable with control tissue. Since PGI2 is a very potent platelet aggregation inhibitor and vasodilator, it is concluded that the increase in PGI2 generation in acute rejection might be a self protecting mechanism which is, however, overwhelmed in irreversible rejection.
在急性和慢性肾移植排斥反应中，通过生物测定法检测肾皮质和髓质组织样本中前列环素（PGI2）的生成情况，并与正常组织进行比较。在急性排斥反应中，PGI2的生成显著增强，尤其是在皮质。在慢性排斥反应中，PGI2的生成与对照组织相当。由于PGI2是一种非常有效的血小板聚集抑制剂和血管扩张剂，因此得出结论，急性排斥反应中PGI2生成的增加可能是一种自我保护机制，然而，在不可逆排斥反应中这种机制会失效。
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