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[脑磷脂与帕金森病:与安慰剂对照的交叉双盲研究]

[Cerebral phospholipids and Parkinson's disease: cross-over double-blind study versus placebo].

作者信息

Casacchia M, Meco G, Corona R, Castellana F, Cusimano G

出版信息

Riv Neurol. 1981 Mar-Apr;51(2):101-13.

PMID:7017886
Abstract

Authors refer in this study their clinical experience with brain cortex phospholipids (BC-PL) in patients affected by Parkinson's disease and treated with L-DOPA plus IDD. It's plain from results elaborated through statistical examinations a positive influence more on motor timing performances (screw-test, gait-test, peg-board test) than each item of Webster rating scale. Moreover getting in connection high nervous functions with motor activity, authors suppose BC-PL have a primary and direct action on cortical cholinergic structures correlated with attention, learning and memory and consequently a secondary action on motor performances.

摘要

作者在本研究中提及了他们在帕金森病患者中使用脑皮质磷脂(BC-PL)并联合左旋多巴加茚地那韦治疗的临床经验。从通过统计检验得出的结果可以明显看出,BC-PL对运动定时表现(螺旋试验、步态试验、钉板试验)的积极影响比对韦伯斯特评定量表的各项指标的影响更大。此外,鉴于高级神经功能与运动活动相关,作者推测BC-PL对与注意力、学习和记忆相关的皮质胆碱能结构有主要和直接作用,因此对运动表现有次要作用。

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