Zierler K, Rogus E M
Trans Assoc Am Physicians. 1980;93:279-82.
We are testing the hypothesis that hyperpolarization is a transducer of insulin action. We listed three criteria that must be met if the hypothesis is to be demonstrated to be correct. So far, questions based on the first two of these criteria have been subjected to test. We have answered, in part, the second condition: electrically-produced hyperpolarization in the absence of insulin was insulinomimetic insofar as it increased specific D-glucose transport. Now we have addressed the first criterion. Insulin-induced hyperpolarization can occur in less than 1 sec, a response more rapid than any other reported effect of insulin. The data are consistent with the hypothesis that hyperpolarization is a transducer of insulin action.
我们正在检验超极化是胰岛素作用的一种转导机制这一假说。我们列出了若要证明该假说正确必须满足的三个标准。到目前为止，基于其中前两个标准的问题已经经过了检验。我们部分地回答了第二个条件：在没有胰岛素的情况下电产生的超极化具有胰岛素样作用，因为它增加了特异性D-葡萄糖转运。现在我们已经解决了第一个标准。胰岛素诱导的超极化可在不到1秒内发生，这一反应比任何其他已报道的胰岛素作用都更快。这些数据与超极化是胰岛素作用的一种转导机制这一假说相符。
