Young R S, Reed T, Norton J A, Christian J C
Am J Hum Genet. 1981 May;33(3):432-42.
Forty-eight digital dermatoglyphic variables in 192 nuclear families were analyzed to search for evidence of major gene effects, utilizing a pair of recently developed statistics called the major gene index (MGI) and offspring-between-parents (OBP) function. They operate on the principle that under a multifactorial blending inheritance scheme an offspring's phenotypic value approximates the midparental value, whereas under major gene inheritance, the child's value more closely resembles that of one of his parents. Both statistics yielded comparable results. All ridge-count variables showed no strong deviation from a multifactorial model. Pattern-type variables gave values suggesting the presence of major gene effects, but these results were probably the consequence of the variables' relatively discrete distributions, since a departure of a variable from a reasonably continuous phenotypic distribution was shown to interfere significantly with the interpretation of both statistics.
对192个核心家庭中的48个数字皮纹变量进行了分析，以寻找主基因效应的证据，采用了一对最近开发的统计方法，即主基因指数（MGI）和亲子间（OBP）函数。它们基于这样的原理：在多因素混合遗传模式下，后代的表型值接近双亲中值，而在主基因遗传下，孩子的值更接近其父母之一的值。两种统计方法得出了可比的结果。所有嵴纹计数变量均未显示出与多因素模型有强烈偏差。模式类型变量给出的值表明存在主基因效应，但这些结果可能是变量相对离散分布的结果，因为已表明一个变量偏离合理的连续表型分布会显著干扰两种统计方法的解释。
