Davis L G, Keeney R E
Am J Hosp Pharm. 1981 Jun;38(6):825-9.
The epidemiology, clinical course, diagnosis, and attempted treatments of herpes genitalis are reviewed. Herpes genitalis is an increasingly common sexually transmitted disease for which there is no effective treatment. It can occur in either sex and is mot commonly first found in patients 14 to 29 years old. Initial exposure to the virus may result in prolonged local symptoms (pain, itching, discharge) and signs (ulcerative lesions) as well as fever, malaise, myalgias, and fatigue. After the initial exposure, the virus may be found in a latent stage in the dorsal nerve root ganglia in the sacral area, and recurrences of disease may ensue. The frequency and clinical course of recurrent genital herpes can be of varying duration and severity. Although antiviral substances, immune potentiators, topical surfactants, and photodynamic inactivation have been used to treat genital herpes infections, there is no proven effective therapy.
本文综述了生殖器疱疹的流行病学、临床病程、诊断及尝试过的治疗方法。生殖器疱疹是一种日益常见的性传播疾病，目前尚无有效治疗方法。男女均可发病，最常见于14至29岁的患者。初次接触该病毒可能导致局部症状（疼痛、瘙痒、分泌物）和体征（溃疡性病变）持续较长时间，以及发热、不适、肌痛和疲劳。初次接触后，病毒可能潜伏在骶区的背根神经节，随后可能会出现疾病复发。复发性生殖器疱疹的发作频率和临床病程长短及严重程度各不相同。虽然抗病毒物质、免疫增强剂、局部表面活性剂和光动力灭活已被用于治疗生殖器疱疹感染，但尚无经证实有效的疗法。
