单纯疱疹性生殖器炎的临床及病毒学病程
Clinical and virologic course of herpes simplex genitalis.
作者信息
Brown Z A, Kern E R, Spruance S L, Overall J C
出版信息
West J Med. 1979 May;130(5):414-21.
The clinical and virologic course of herpes simplex genitalis in women and men was examined in order to identify measurements useful in antiviral trials. Factors influencing the clinical course included initial disease versus recurrent disease, wet-skin versus dry-skin lesions, female versus male sex. Women with initial genital herpes had higher mean peak lesion virus titers than those with recurrent disease (10(4.5) pfu compared with 10(2.5) pfu) and excreted virus longer (13 to 15 days compared with 6 to 8 days). Men with recurrent lesions had higher mean peak virus titers than women (10(4.0) pfu compared with 10(2.5) pfu), but the duration of virus excretion was shorter (three to four days compared with six to eight days). There was pronounced variation in the clinical and virologic course of recurrent lesions among different patients and even within the same patient. These observations indicate several difficulties that must be considered in conducting careful antiviral trials in patients with herpes simplex genitalis.
为了确定在抗病毒试验中有用的衡量指标，对女性和男性单纯疱疹性生殖器疱疹的临床和病毒学病程进行了研究。影响临床病程的因素包括初发性疾病与复发性疾病、湿性皮肤病变与干性皮肤病变、女性与男性。初发性生殖器疱疹的女性平均峰值病变病毒滴度高于复发性疾病的女性（分别为10(4.5) 噬斑形成单位与10(2.5) 噬斑形成单位），且病毒排泄时间更长（分别为13至15天与6至8天）。复发性病变的男性平均峰值病毒滴度高于女性（分别为10(4.0) 噬斑形成单位与10(2.5) 噬斑形成单位），但病毒排泄持续时间较短（分别为三至四天与六至八天）。不同患者之间甚至同一患者体内复发性病变的临床和病毒学病程存在显著差异。这些观察结果表明，在对单纯疱疹性生殖器疱疹患者进行严谨的抗病毒试验时，必须考虑到几个困难之处。
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