Studies on the treatment and prevention of colorectal liver metastases.

Liver metastases occur in as many as 50% of patients with colorectal cancer and are regarded as a principal cause of death. Both clinical and experimental studies have been undertaken in an attempt to understand the haemodynamic changes occurring in established liver metastases. Trials of various forms of treatment based on these observations are described. In addition attempts to reduce the incidence of subsequent liver metastases are discussed.