Spark R P
Arch Pathol Lab Med. 1981 Jul;105(7):347-50.
A neonatal death due to unsuspected coccidioidomycosis was studied. A critical review of the 12 neonatal fatalities and two survivals now reported strongly opposes the concept of transplacental spread. Associated with 35 maternal fatalities in the literature are 16 cases of placentitis and five neonatal deaths; none of the neonatal deaths, however, were associated with placentitis. Three of these five had predominantly intrathoracic disease, as did those neonates whose rapid deaths were unassociated with maternal coccidioidomycosis. Transpartum aspiration of infected decidua or postpartum inhalation is the probable initial pathogenic event in neonatal coccidioidomycosis.
对一例因未被怀疑的球孢子菌病导致的新生儿死亡病例进行了研究。对目前报告的12例新生儿死亡病例和2例存活病例进行的严格审查强烈反对经胎盘传播这一概念。文献中35例孕产妇死亡病例伴有16例胎盘炎和5例新生儿死亡；然而，这些新生儿死亡病例均与胎盘炎无关。这5例中有3例主要为胸腔内疾病，那些快速死亡且与母亲球孢子菌病无关的新生儿也是如此。感染蜕膜的经产道抽吸或产后吸入可能是新生儿球孢子菌病最初的致病事件。
