England J D
Aust N Z J Med. 1981 Feb;11(1):35-40. doi: 10.1111/j.1445-5994.1981.tb03733.x.
Atenolol, Pindolol and Propranolol in single daily doses administered to 18 selected patients with mild essential hypertension achieved adequate control of blood pressure. Chlorothiazide had been initially administered twice a day without full control of blood pressure and this diuretic therapy was continued unaltered throughout the study. Methacholine challenge testing of respiratory function was performed during the placebo phase and with each beta adrenoreceptor-blocking drug. In the 18 non-asthmatic patients, the reduction in FEV1, was significant only for propranolol therapy when compared to placebo. Each beta adrenoreceptor-blocking drug was associated with small, but significant, increases in fasting plasma triglyceride concentrations and suppression of fasting immuno-reactive glucagon concentrations.
对18例选定的轻度原发性高血压患者每日单次服用阿替洛尔、吲哚洛尔和普萘洛尔，血压得到了充分控制。最初每日服用两次氯噻嗪，但血压未得到完全控制，且在整个研究过程中利尿剂治疗未改变。在安慰剂阶段以及使用每种β肾上腺素受体阻滞剂期间，进行了呼吸功能的乙酰甲胆碱激发试验。在18例非哮喘患者中，与安慰剂相比，仅普萘洛尔治疗时第一秒用力呼气量（FEV1）降低显著。每种β肾上腺素受体阻滞剂均与空腹血浆甘油三酯浓度小幅但显著升高以及空腹免疫反应性胰高血糖素浓度受抑制有关。
