Nakao J, Change W C, Murota S I, Orimo H
Atherosclerosis. 1981 May;39(2):203-9. doi: 10.1016/0021-9150(81)90070-8.
The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10(-10)-10(-6) M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70%) was observed when cells were treated with a physiological concentration of 19(-8) M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.
利用培养的大鼠主动脉平滑肌细胞研究了睾酮对细胞增殖和前列环素生成的影响。10(-10)-10(-6)M的睾酮对细胞增殖没有任何显著影响，但它显著抑制了细胞的前列环素生成。当细胞用19(-8)M的生理浓度睾酮连续处理5天时，观察到前列环素生成的最大抑制（70%）。这些结果表明，睾酮可能通过抑制动脉平滑肌细胞中的前列环素生成来刺激血栓形成并加速动脉粥样硬化。
