[Participation of spleen cells in regulating the production of macrophage migration inhibitory factor in mice].

The effect of the spleen on migration inhibition factor (MIF) production in adult thymectomized and intact C57BL mice and in hybrids F1 (C57BL X CBA) was studied. Splenectomy itself was shown not to influence MIF production. However, the removal of the spleen both before and after thymectomy favoured the maintenance of MIF production impaired after thymectomy. Addition of spleen cells from thymectomized mice to immune syngeneic cells of peritoneal exudate from intact mice in different concentrations abolishes MIF production. The effect of suppression of MIF production is related to adherent spleen cells from adult thymectomized mice. It is assumed that these cells might be T1-lymphocytes.