[脾细胞参与调节小鼠巨噬细胞移动抑制因子的产生]
[Participation of spleen cells in regulating the production of macrophage migration inhibitory factor in mice].
作者信息
Koval'chuk L V, Sotnikova N Iu
出版信息
Biull Eksp Biol Med. 1981 Mar;91(3):336-8.
The effect of the spleen on migration inhibition factor (MIF) production in adult thymectomized and intact C57BL mice and in hybrids F1 (C57BL X CBA) was studied. Splenectomy itself was shown not to influence MIF production. However, the removal of the spleen both before and after thymectomy favoured the maintenance of MIF production impaired after thymectomy. Addition of spleen cells from thymectomized mice to immune syngeneic cells of peritoneal exudate from intact mice in different concentrations abolishes MIF production. The effect of suppression of MIF production is related to adherent spleen cells from adult thymectomized mice. It is assumed that these cells might be T1-lymphocytes.
研究了脾脏对成年去胸腺和完整的C57BL小鼠以及杂种F1（C57BL×CBA）中迁移抑制因子（MIF）产生的影响。脾切除本身并未显示出对MIF产生有影响。然而，在胸腺切除前后切除脾脏有利于维持胸腺切除后受损的MIF产生。将去胸腺小鼠的脾细胞以不同浓度添加到完整小鼠腹腔渗出液的同基因免疫细胞中可消除MIF的产生。抑制MIF产生的作用与成年去胸腺小鼠的贴壁脾细胞有关。据推测，这些细胞可能是T1淋巴细胞。
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