[干细胞抑制因子和巨噬细胞抑制因子对小鼠脾细胞体外定植及迁移的影响]
[Effect of stem cell inhibition factor and macrophage inhibition factor on mouse spleen cell exocolonization and migration].
作者信息
Mysiakin E B, Suslov A P, Golovanova T A, Kaulen D R
出版信息
Biull Eksp Biol Med. 1978 Sep;86(9):344-7.
The migration activity of the spleen cells from intact mice is inhibited by the stem cell inhibitory factor (SCIF) released by lymphocytes treated with antilymphocytic globulin. The degree of the migration inhibition is proportional to the activity of SCIF in the colony-formation inhibition. The macrophage-migration inhibitory factor (MIF), obtained in the H-2 system exhibited a stimulating effect on the colony formation in mice when used in vitro for the treatment of bone marrow transplants. This activity of MIF corresponds to its migration-inhibitory effect on the spleen cells. Incubation of the bone marrow cells with MIF for 30 minutes is more effective than the 2-hour treatment. The observed effects are interpreted as an indication of non-identity of SCIF and MIF.
用抗淋巴细胞球蛋白处理的淋巴细胞释放的干细胞抑制因子（SCIF）可抑制正常小鼠脾细胞的迁移活性。迁移抑制程度与SCIF在集落形成抑制中的活性成正比。在H-2系统中获得的巨噬细胞迁移抑制因子（MIF），在体外用于治疗骨髓移植时，对小鼠的集落形成有刺激作用。MIF的这种活性与其对脾细胞的迁移抑制作用相对应。将骨髓细胞与MIF孵育30分钟比处理2小时更有效。观察到的这些效应被解释为SCIF和MIF不相同的一个指标。
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