Morimoto S, Yamamoto I, Uchida K, Funatsu T, Fujimura A, Honjo A, Takeda R, Kigoshi T
Cardiology. 1981;67(4):219-29. doi: 10.1159/000173247.
Hemodynamic effects of [Sar1, Ile8] AII, an angiotensin II analog, were studied in 30 patients with essential hypertension, who were subdivided into 11 low renin, 10 normal renin and 9 high renin groups according to low, normal and high PRA values both before and after furosemide administration (80 mg, orally) plus 4 h of ambulation, respectively. [Sar1, Ile8] AII infusion (600 ng/kg/min) produced significant increases in mean blood pressure (MBP) and total peripheral resistance index (TPRI) in normal renin and low renin groups and significant decreases in MBP and TPRI in high renin group, while the cardiac index and heart rate remained unchanged during the infusion in these three groups. Change in MBP at 30 min of [Sar1, Ile8] AII infusion correlated significantly with alteration in TPRI in 23 patients with essential hypertension, who completed the 30-min infusion. The response of both MBP and TPRI to [SAR1, Ile8] AII also correlated significantly with basal PRA. These results suggest that blood pressure response to [SAR1, Ile8] AII in essential hypertension is primarily due to alteration in total peripheral resistance and that direction and amplitude of the response of both MBP and TPRI are practically dependent on basal PRA levels.
对30例原发性高血压患者研究了血管紧张素II类似物[Sar1，Ile8] AII的血流动力学效应。这些患者根据口服80mg速尿加4小时活动前后的血浆肾素活性（PRA）值低、正常和高，分别分为11例低肾素、10例正常肾素和9例高肾素组。[Sar1，Ile8] AII输注（600ng/kg/min）使正常肾素组和低肾素组的平均血压（MBP）和总外周阻力指数（TPRI）显著升高，高肾素组的MBP和TPRI显著降低，而这三组输注期间心脏指数和心率保持不变。在完成30分钟输注的23例原发性高血压患者中，[Sar1，Ile8] AII输注30分钟时MBP的变化与TPRI的改变显著相关。MBP和TPRI对[SAR1，Ile8] AII的反应也与基础PRA显著相关。这些结果表明，原发性高血压患者对[SAR1，Ile8] AII的血压反应主要是由于总外周阻力的改变，并且MBP和TPRI反应的方向和幅度实际上取决于基础PRA水平。
