老年高血压患者使用血管紧张素II拮抗剂的肾素-血管紧张素-醛固酮系统研究。

Studies on the renin-angiotensin-aldosterone system in elderly hypertensive patients with an angiotensin II antagonist.

Ogihara T, Hata T, Maruyama A, Mikami H, Nakamaru M, Mandai T, Kumahara Y

Clin Sci (Lond). 1979 Nov;57(5):461-3. doi: 10.1042/cs0570461.

Abstract

To characterize the renin-angiotensin-aldosterone system in elderly hypertensive patients, an angiotensin II antagonist, [Sar1,Ile8]angiotensin II, was infused into individuals 60 years old and older with and without hypertension. 2. After infusion of [Sar1,Ile8]angiotensin II in all of the elderly patients and subjects an agonistic pressor response was observed that was greater than in middle-aged hypertensive patients. 3. Pre-infusion plasma renin activity and plasma aldosterone concentration in hypertensive and normotensive elderly groups were suppressed in comparison with those in middle-aged hypertensive subjects. The increased agonistic effects of [Sar1,Ile8]angiotensin II infusion on blood pressure in the elderly are presumably due to their hyporeninaemia. 4. The angiotensin-aldosterone system in elderly essential hypertensive patients is suppressed and is presumably not responsible for their elevated blood pressures.

摘要

为了描述老年高血压患者的肾素 - 血管紧张素 - 醛固酮系统，将一种血管紧张素II拮抗剂，即[Sar1，Ile8]血管紧张素II，输注到60岁及以上患有和未患有高血压的个体中。2. 在所有老年患者和受试者中输注[Sar1，Ile8]血管紧张素II后，观察到一种激动性升压反应，该反应比中年高血压患者更强烈。3. 与中年高血压受试者相比，高血压和血压正常的老年组在输注前的血浆肾素活性和血浆醛固酮浓度受到抑制。[Sar1，Ile8]血管紧张素II输注对老年人血压的激动作用增强可能是由于他们的低肾素血症。4. 老年原发性高血压患者的血管紧张素 - 醛固酮系统受到抑制，可能与其血压升高无关。