Sutherland B M
J Invest Dermatol. 1981 Jul;77(1):91-5. doi: 10.1111/1523-1747.ep12479267.
In many procaryotic and eucaryotic cells, photoreactivating enzyme mediates light-dependent repair of UV-induced damage: the enzyme binds to a pyrimidine dimer in DNA, and, on absorption of a photon (300-600 nm), specifically monomerizes the dimer, thus repairing the DNA. Photoreactivating enzyme has been found in human tissues and human cells in culture; human cells in culture can photoreactivate cellular dimers, and can mediate photoreactivation of Herpes (human fibroblasts) and Epstein-Barr virus (human leukocytes). Measurements of pyrimidine dimer formation and repair in human skin indicate that detectable numbers of dimers are formed at 1 minimal erythemal dose, that the dimers are rapidly removed in skin kept in the absence of light, and they are more rapidly removed when the skin is exposed to visible light.
在许多原核细胞和真核细胞中，光复活酶介导紫外线诱导损伤的光依赖性修复：该酶与DNA中的嘧啶二聚体结合，并且在吸收一个光子（300 - 600纳米）后，特异性地使二聚体单体化，从而修复DNA。在人体组织和培养的人体细胞中已发现光复活酶；培养的人体细胞可以使细胞内的二聚体光复活，并且可以介导疱疹病毒（人成纤维细胞）和爱泼斯坦 - 巴尔病毒（人白细胞）的光复活。对人体皮肤中嘧啶二聚体形成和修复的测量表明，在1个最小红斑剂量下会形成可检测数量的二聚体，这些二聚体在避光保存的皮肤中会迅速被清除，而当皮肤暴露于可见光时，它们会被更快地清除。
