Peptide uptake in Candida albicans.

Transport of radioactively labelled peptides has been used to characterize a common transport system for di- and tripeptides in Candida albicans. This permease is energy-dependent and has a requirement for L-amino acid residues, an alpha-linkage between residues and a free amino terminus. Transport was followed by the accumulation inside the cell of intact peptides and component amino acids. After transport of glycyl-[U-14C]phenylalanine the radioactive material was accumulated inside the cell and subsequently leaked into the medium under certain conditions.