Tsuda K, Seino Y, Mori K, Seino S, Takemura J, Kuzuya H, Yamamura T, Kotoura Y, Ito N, Imura H
Regul Pept. 1981 Feb;1(5):347-52. doi: 10.1016/0167-0115(81)90058-6.
Intravenous glucose infusion was performed in six dogs with and without truncal vagotomy, and plasma pancreatic polypeptide (PP) responses were compared before and after truncal vagotomy. Following truncal vagotomy, basal PP levels decreased significantly from 286 +/- 64 pg/ml (mean +/- S.E.) to 94 +/- 14 pg/ml (P less than 0.05). Basal plasma insulin and blood glucose levels also tended to be lower, but not significantly. During the infusion of glucose, blood glucose concentrations rose rapidly in both groups and after 15 min reached peak values which were not significantly different from each other. In the vagotomized group the plasma insulin response to intravenous glucose infusion was significantly lower than in the control group. Following intravenous glucose loading, plasma PP concentrations decreased rapidly in both groups, but the PP level in the vagotomized group was suppressed only to 77 +/- 4% of the basal level whereas in the control group it decreased by 45 +/- 8%, significantly lower than in the vagotomized group (P less than 0.01). These results suggest that basal PP is regulated by vagal tonus and that vagus controls, at least in part, suppression by intravenous glucose administration.
对6只犬进行了静脉输注葡萄糖试验，其中部分犬进行了迷走神经干切断术，部分未进行。比较了迷走神经干切断术前后血浆胰多肽（PP）的反应。迷走神经干切断术后，基础PP水平从286±64 pg/ml（平均值±标准误）显著降至94±14 pg/ml（P<0.05）。基础血浆胰岛素和血糖水平也有降低趋势，但不显著。在输注葡萄糖过程中，两组血糖浓度均迅速升高，15分钟后达到峰值，两组峰值无显著差异。迷走神经切断组对静脉输注葡萄糖的血浆胰岛素反应显著低于对照组。静脉输注葡萄糖负荷后，两组血浆PP浓度均迅速下降，但迷走神经切断组PP水平仅降至基础水平的77±4%，而对照组则下降了45±8%，显著低于迷走神经切断组（P<0.01）。这些结果表明，基础PP受迷走神经张力调节，迷走神经至少部分控制静脉输注葡萄糖引起的PP抑制。
