Katz J L
Symp Soc Exp Biol. 1980;34:137-68.
An attempt has been made to present a uniform view of studies of bone which have as their raison d'etre an understanding of the 'form-function' relationship. This is the key to understanding the mechanisms controlling the growth, development and behavior of bone as a dynamic biological system in its response to the mechanical stresses imposed through both normal and pathological conditions. Studies of structure at various levels of organization were presented both in themselves as well as where correlated with mechanical measurements; similarly, mechanical measurements alone were described as well as studies in which the mechanical properties were correlated with structural studies. These studies are presenting sufficient details for a picture to begin to form with enough resolution to provide a standard against which to test models which attempt to describe Wolff's Law mechanisms (form predicating function nd vice versa) as well as models which attempt to understand what is responsible for the material properties of bone. The hierarchical composite modeling which closes this paper is such an attempt at the latter problem. The modeling is rooted in both the structural studies and mechanical measurements thus closing the loop.
本文试图对关于骨骼的研究提出一个统一的观点，这些研究的存在理由是对“形态-功能”关系的理解。这是理解控制骨骼作为一个动态生物系统在正常和病理条件下对机械应力作出反应时的生长、发育和行为机制的关键。本文既介绍了不同组织层次的结构研究本身，也介绍了与力学测量相关的结构研究；同样，既描述了单独的力学测量，也介绍了力学性能与结构研究相关的研究。这些研究提供了足够的细节，一幅具有足够分辨率的图景开始形成，从而提供一个标准，用以检验试图描述沃尔夫定律机制（形态决定功能，反之亦然）的模型，以及试图理解骨骼材料特性成因的模型。本文结尾的层次复合建模就是针对后一个问题的这样一种尝试。该建模基于结构研究和力学测量，从而形成了一个闭环。
