Schreiner R L, Lemons J A, Gresham E L
Ann Nutr Metab. 1981;25(1):38-47. doi: 10.1159/000176477.
The purpose of this study was to investigate the metabolic adaptations of the fetus during maternal starvation and to determine the changes of plasma insulin and glucagon concentrations in the fed state and during severe maternal fasting in the chronic fetal sheep preparation. Maternal fasting resulted in a decrease in maternal and fetal plasma glucose as well as a decrease in fetal plasma fructose. Fetal-maternal arterial urea concentration differences increased with maternal fasting, suggesting increased fetal amino acid catabolism. Both maternal anf fetal plasma insulin decreased parallel to the decrease in plasma glucose concentration. Maternal glucagon did not change significantly during fasting and with a short-term fast there was no change in fetal glucagon concentration. However, by 6 days of fasting, the fetal glucagon concentration tended to increase.
本研究的目的是调查母体饥饿期间胎儿的代谢适应性，并确定在慢性胎儿绵羊制备中，进食状态下以及母体严重禁食期间血浆胰岛素和胰高血糖素浓度的变化。母体禁食导致母体和胎儿血浆葡萄糖水平下降，以及胎儿血浆果糖水平降低。随着母体禁食，胎儿-母体动脉尿素浓度差异增加，提示胎儿氨基酸分解代谢增强。母体和胎儿血浆胰岛素均随血浆葡萄糖浓度的下降而平行降低。禁食期间母体胰高血糖素无显著变化，短期禁食时胎儿胰高血糖素浓度也无变化。然而，禁食6天时，胎儿胰高血糖素浓度有升高趋势。
