使用多价肺炎球菌疫苗进行免疫接种。对生活在新几内亚高地儿童呼吸道死亡率的影响。
Immunisation with a polyvalent pneumococcal vaccine. Effect of respiratory mortality in children living in the New Guinea highlands.
作者信息
Riley I D, Everingham F A, Smith D E, Douglas R M
出版信息
Arch Dis Child. 1981 May;56(5):354-7. doi: 10.1136/adc.56.5.354.
Abstract
In Tari, in the southern highlands of Papua New Guinea, each child experienced, on average, two acute lower respiratory tract infections (ALRTI) between birth and age 5 years. The yearly mortality rate from ALRTI was 30 per 1000 in infants, and 4 per 1000 in children aged between 1 and 4 years. A double-blind trial of a 14-valent pneumococcal polysaccharide vaccine was carried out on 871 children from this community who were aged between 6 months and 5 years. Morbidity from ALRTI was lower (by 37%) in children given the vaccine provided they were at least 17 months of age at the time of immunisation. There were 8 deaths from ALRTI in the placebo group, but only 1 death in the vaccine group.
摘要
在巴布亚新几内亚南部高地的塔里，每个儿童在出生至5岁期间平均经历两次急性下呼吸道感染（ALRTI）。婴儿期ALRTI的年死亡率为每1000人中有30人，1至4岁儿童为每1000人中有4人。对该社区871名年龄在6个月至5岁之间的儿童进行了14价肺炎球菌多糖疫苗的双盲试验。如果接种疫苗的儿童在免疫时至少17个月大，那么他们患ALRTI的发病率较低（降低了37%）。安慰剂组有8例死于ALRTI，但疫苗组只有1例死亡。
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