Husz S, Szabó E, Berkò G, Hunyadi J, Dobozy A, Simon N
Diagn Histopathol. 1981 Apr-Jun;4(2):149-55.
Disorders of serum proteins, circulating antibodies, immune complexes to the dermo-epidermal junction, B- and T-cell markers from peripheral blood lymphocytes and the suppressor function of peripheral mononuclear cells have been investigated in 106 patients with histologically proven discoid lupus erythematosus (discoid LE). The results confirm that this condition is primarily a localized skin disease with low concentrations of autoantigens and circulating autoantibodies. By contrast, systemic lupus erythematosus (systemic LE) is a multifocal, generalized disease with high concentrations of autoantigens, autoantibodies and immune complexes. The transformation of discoid LE to systemic LE is discussed, and a possible two-hit mechanism is proposed.
对106例经组织学证实为盘状红斑狼疮（盘状LE）的患者，研究了血清蛋白、循环抗体、针对真皮 - 表皮交界处的免疫复合物、外周血淋巴细胞的B细胞和T细胞标志物以及外周单核细胞的抑制功能。结果证实，这种情况主要是一种局部性皮肤病，自身抗原和循环自身抗体浓度较低。相比之下，系统性红斑狼疮（系统性LE）是一种多灶性、全身性疾病，自身抗原、自身抗体和免疫复合物浓度较高。讨论了盘状LE向系统性LE的转变，并提出了一种可能的二次打击机制。
