Kuckelt W, Scharfenberg J, Mrochen H, Dauberschmidt R, Petrakov G, Kassil W, Meyer M
Intensive Care Med. 1981;7(4):177-85. doi: 10.1007/BF01724838.
The effect of positive end-expiratory pressure on a value resulting in maximum static effective compliance was studied in 13 artificially ventilated patients suffering from adult respiratory distress syndrome. Applying positive end-expiratory pressure in this manner resulted in improvement of oxygen delivery and left ventricular stroke work. In the patients with high venous admixture under zero end-expiratory pressure cardiac output increased but in those with moderate pre-existing venous admixture cardiac output decreased. We conclude that the response to positive end-expiratory pressure depends on the importance of the venous admixture. Artificial ventilation with positive end-expiratory pressure on a level resulting in maximum static effective compliance is indicated in cases with high venous admixture.
对13例患有成人呼吸窘迫综合征的人工通气患者研究了呼气末正压对导致最大静态有效顺应性值的影响。以这种方式应用呼气末正压可改善氧输送和左心室搏功。在呼气末压力为零时静脉血掺杂高的患者中，心输出量增加，但在已有中度静脉血掺杂的患者中，心输出量降低。我们得出结论，对呼气末正压的反应取决于静脉血掺杂的程度。对于静脉血掺杂高的病例，建议采用能产生最大静态有效顺应性水平的呼气末正压进行人工通气。
