Husseini R, Stretton R J
Microbios. 1980;29(116):109-25.
Phanquone is active against a wide range of Gram-positive and Gram-negative organisms. Its activity is affected by the nature of the suspending fluid, pH and anaerobic growth conditions. Its ability to chelate metal ions was examined and found to be related to its antibacterial activity, which was reduced by the presence of added metal ions, e.g. Co (II), Cu(II), Fe(II) and Fe(III) in nutrient media for both E. coli and S. aureus. When antibacterial activity was examined in dis-nutrient media for both E. coli and S. aureus. When antibacterial activity was examined in distilled water, then certain added metal ions, whilst antagonizing activity was examined in distilled water, then certain added metal ions, whilst antagonizing the activity of Phanquone against E. coli, exerted a co-operative effect in the case of S. aureus. The addition of EDTA and NTA lowered the activity of Phanquone against S. aureus, but not E. coli, while the addition of thiol-containing compounds lowered its activity against E. coli but not S. aureus. concentration quenching was observed for S. aureus but not for E. coli, while overnight pre-incubation at 4 degrees C resulted in the appearance of a growth zone inside the zone of inhibition in the case of S. aureus but not E. coli. Phanquone may have a different mode of action against the two organisms.
泛醌对多种革兰氏阳性菌和革兰氏阴性菌具有活性。其活性受悬浮液性质、pH值和厌氧生长条件的影响。研究了其螯合金属离子的能力，发现这与其抗菌活性有关，在营养培养基中添加金属离子（如大肠杆菌和金黄色葡萄球菌培养基中的Co (II)、Cu(II)、Fe(II)和Fe(III)）会降低其抗菌活性。当在大肠杆菌和金黄色葡萄球菌的双营养培养基中检测抗菌活性时，在蒸馏水中检测抗菌活性时，某些添加的金属离子在拮抗泛醌对大肠杆菌活性的同时，对金黄色葡萄球菌却发挥协同作用。添加EDTA和NTA会降低泛醌对金黄色葡萄球菌的活性，但对大肠杆菌无影响，而添加含硫醇化合物会降低其对大肠杆菌的活性，但对金黄色葡萄球菌无影响。观察到金黄色葡萄球菌存在浓度猝灭现象，而大肠杆菌没有，在4℃下过夜预孵育后，金黄色葡萄球菌的抑菌圈内出现了生长区，而大肠杆菌没有。泛醌对这两种细菌可能具有不同的作用方式。
