作为潜在抗惊厥剂的1-甲基-2-苯基氨基甲酰基吡唑烷的合成。
Synthesis of 1-methyl-2-phenylcarbamoylpyrazolidines as potential anticonvulsant agents.
作者信息
Kornet M J
出版信息
J Pharm Sci. 1978 Oct;67(10):1471-3. doi: 10.1002/jps.2600671042.
PMID:702307
Abstract
Lithium aluminum hydride reduction of 1,4-dimethyl-3-pyrazolidinone yielded 1,4-dimethylpyrazolidine. The latter compound and 1-methylpyrazolidine reacted with aryl isocyanates to produce 1-methyl-2-phenylcarbamoylpyrazolidines. Several of these adducts displayed significant anticonvulsant activity in the maximal electroshock seizure and pentylenetetrazol seizure threshold tests.
摘要
氢化铝锂还原1,4 - 二甲基 - 3 - 吡唑烷酮生成1,4 - 二甲基吡唑烷。后一种化合物与1 - 甲基吡唑烷与芳基异氰酸酯反应生成1 - 甲基 - 2 - 苯基氨基甲酰基吡唑烷。其中几种加合物在最大电休克惊厥和戊四氮惊厥阈值试验中表现出显著的抗惊厥活性。
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