喹唑啉基甲脒类和喹唑啉二基双甲脒类作为抗高血压药物。
Quinazolinylformamidines and quinazolinediylbisformamidines as antihypertensive agents.
作者信息
Warren J D, Lang S A, Chan P S, Marsico J W
出版信息
J Pharm Sci. 1978 Oct;67(10):1479-81. doi: 10.1002/jps.2600671046.
PMID:702310
Abstract
Eleven quinazolinylformamidines and quinazolinediylbisformamidines were synthesized and investigated for antihypertensive activity in spontaneous hypertensive rats. Several compounds showed moderate antihypertensive activity at 100 mg/kg po. The same compounds were not hypotensive in the normotensive dog.
摘要
合成了11种喹唑啉基甲脒和喹唑啉二基双甲脒，并在自发性高血压大鼠中研究了它们的抗高血压活性。几种化合物在口服100mg/kg时显示出中等程度的抗高血压活性。相同的化合物在正常血压的狗中不会引起低血压。
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