Suppression of the hypothalamic-pituitary-adrenal axis after a single intramuscular injection of methylprednisolone acetate.

Fourteen patients with hay fever were treated with one intramuscular injection of methylprednisolone acetate, which gave satisfactory symptomatic relief for three weeks. Their hypothalamic-pituitary-adrenal function was moderately but significantly suppressed for three weeks but became normal again after four weeks.