Engström B, Borg E
Arch Otorhinolaryngol. 1981;230(3):279-84. doi: 10.1007/BF00456330.
A total of 28 un-anesthetized rabbits of the small chinchilla strain were unilaterally exposed to noise (2-7 kHz, 135 dB SPL in the ear canal). After a follow-up time ranging from 15 minutes to 10 months, the ears were perfused with glutaraldehyde and prepared for analysis by secondary emission electron microscopy and transmission electron microscopy. The typical finding was a fusion and clumping of inner hair cell (IHC) sensory hairs. In two of the animals, no loss of outer hair cells (OHC) was observed; in several of the others, only a small local loss of OHC was observed in the 2 and 4 kHz regions in spite of extensive IHC abnormality. A frequency map of the rabbit cochlea was obtained by pure tone lesions to OHC. The extent of IHC abnormalities corresponds to the 1-16 kHz region. The findings may provide a basis for the study of the functional relationship between the IHC and OHC.
总共28只小毛丝鼠品系的未麻醉兔子被单侧暴露于噪声（2 - 7千赫兹，耳道内声压级为135分贝）。在15分钟至10个月的随访期后，用戊二醛灌注耳朵，并制备用于二次发射电子显微镜和透射电子显微镜分析的样本。典型的发现是内毛细胞（IHC）感觉毛的融合和结块。在其中两只动物中，未观察到外毛细胞（OHC）损失；在其他几只动物中，尽管内毛细胞有广泛异常，但仅在2千赫兹和4千赫兹区域观察到外毛细胞有小范围的局部损失。通过对豚鼠外毛细胞进行纯音损伤获得了兔子耳蜗的频率图。内毛细胞异常的范围对应于1 - 16千赫兹区域。这些发现可能为研究内毛细胞和外毛细胞之间的功能关系提供基础。
