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遗传性肾炎中抗肾小球基底膜结合的变异性

Variability of anti-GBM binding in hereditary nephritis.

作者信息

Jenis E H, Valeski J E, Calcagno P L

出版信息

Clin Nephrol. 1981 Mar;15(3):111-4.

PMID:7023765
Abstract

Anti-GBM staining by indirect immunofluorescence microscopy was performed on renal biopsies from 64 patients with a variety of diseases in which no in vivo bound immunoglobulin or complement components were identified by direct immunofluorescence microscopy. The glomeruli of all of the entities examined bound anti-GBM antibodies except for four of nine cases of hereditary nephritis of the Alport-type. The absence of anti-GBM staining was found to correlate with the severity of GBM splitting identified by electron microscopy.

摘要

对64例患有各种疾病的患者的肾活检组织进行间接免疫荧光显微镜抗肾小球基底膜(GBM)染色,这些患者通过直接免疫荧光显微镜未发现体内结合的免疫球蛋白或补体成分。除9例Alport型遗传性肾炎中的4例之外,所有检查实体的肾小球均结合抗GBM抗体。发现抗GBM染色缺失与电子显微镜鉴定的GBM分裂严重程度相关。

相似文献

1
Variability of anti-GBM binding in hereditary nephritis.遗传性肾炎中抗肾小球基底膜结合的变异性
Clin Nephrol. 1981 Mar;15(3):111-4.
2
Distribution of familial nephritis antigen in normal tissue and renal basement membranes of patients with homozygous and heterozygous Alport familial nephritis. Relationship of familial nephritis and Goodpasture antigens to novel collagen chains and type IV collagen.家族性肾炎抗原在正常组织以及纯合子和杂合子Alport家族性肾炎患者肾基底膜中的分布。家族性肾炎和Goodpasture抗原与新型胶原链及IV型胶原的关系。
Lab Invest. 1989 Sep;61(3):278-89.
3
Hereditary nephritis: immunoblotting studies of the glomerular basement membrane.遗传性肾炎:肾小球基底膜的免疫印迹研究
Lab Invest. 1989 May;60(5):613-8.
4
Linear glomerular IgG fixation in renal allografts: incidence and significance in Alport's syndrome.肾移植中线性肾小球IgG沉积:在Alport综合征中的发生率及意义
Clin Nephrol. 1986 Mar;25(3):134-40.
5
Renal disease in carrier female dogs with X-linked hereditary nephritis. Implications for female patients with this disease.患有X连锁遗传性肾炎的雌性犬携带者的肾脏疾病。对患有这种疾病的女性患者的启示。
Am J Pathol. 1991 Oct;139(4):751-64.
6
[Glomerulonephritis by glomerular anti-basement membrane antibodies after renal transplantation].肾移植后肾小球抗基底膜抗体所致肾小球肾炎
Nephrologie. 1989;10(3):113-5.
7
Allograft rejection and glomerular basement membrane antibodies in Alport's syndrome.Alport综合征中的同种异体移植排斥反应和肾小球基底膜抗体。
J Nephrol. 2004 May-Jun;17(3):431-5.
8
The glomerular basement membrane defect in Alport-type hereditary nephritis: absence of cationic antigenic components.奥尔波特型遗传性肾炎中的肾小球基底膜缺陷:阳离子抗原成分缺失。
Nephrol Dial Transplant. 1989;4(9):770-5.
9
Immunofluorescence study of type IV collagen alpha chains in epidermal basement membrane: application in diagnosis of X-linked Alport syndrome.表皮基底膜中IV型胶原α链的免疫荧光研究:在X连锁Alport综合征诊断中的应用
Chin Med J (Engl). 1997 Aug;110(8):584-6.
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Characterisation and specificity of glomerular basement membrane antigens identified by sera of patients with anti-GBM nephritis.抗肾小球基底膜肾炎患者血清所识别的肾小球基底膜抗原的特征与特异性
Nephrol Dial Transplant. 1986;1(3):155-63.

引用本文的文献

1
Development and heterogeneity of antigens in the immature nephron. Reactivity with human antiglomerular basement membrane autoantibodies.未成熟肾单位中抗原的发育与异质性。与人抗肾小球基底膜自身抗体的反应性。
Am J Pathol. 1984 Nov;117(2):180-3.
2
Amyloid P component is not present in the glomerular basement membrane in Alport-type hereditary nephritis.淀粉样P成分在奥尔波特型遗传性肾炎的肾小球基底膜中不存在。
Am J Pathol. 1986 Dec;125(3):460-4.
3
Urinary excretion of glomerular basement membrane-related peptides in children with renal disorders.
肾脏疾病患儿肾小球基底膜相关肽的尿排泄情况。
Pediatr Nephrol. 1987 Jul;1(3):428-35. doi: 10.1007/BF00849249.
4
An immunohistochemical and electron microscopic study of extra-renal basement membranes in dogs with Samoyed hereditary glomerulopathy.萨摩耶遗传性肾小球病犬肾外基底膜的免疫组织化学和电子显微镜研究
Virchows Arch A Pathol Anat Histopathol. 1988;412(3):281-90. doi: 10.1007/BF00737153.
5
Immunohistochemical localization of glomerular basement membrane antigens in various renal diseases.各种肾脏疾病中肾小球基底膜抗原的免疫组织化学定位
Virchows Arch A Pathol Anat Histopathol. 1986;408(4):403-19. doi: 10.1007/BF00707698.
6
Alport's syndrome.阿尔波特综合征
J Med Genet. 1988 Sep;25(9):623-7. doi: 10.1136/jmg.25.9.623.
7
The NC1 domain of collagen type IV in neonatal dog glomerular basement membranes. Significance in Samoyed hereditary glomerulopathy.新生犬肾小球基底膜中IV型胶原的NC1结构域。在萨摩耶遗传性肾小球病中的意义。
Am J Pathol. 1989 May;134(5):1047-54.
8
Nephritogenic antigen determinants in epidermal and renal basement membranes of kindreds with Alport-type familial nephritis.患有奥尔波特型家族性肾炎的家族中,表皮和肾基底膜中的致肾炎抗原决定簇。
J Clin Invest. 1986 Oct;78(4):1035-44. doi: 10.1172/JCI112658.
9
Alport syndrome, basement membranes and collagen.阿尔波特综合征、基底膜与胶原蛋白。
Pediatr Nephrol. 1990 Sep;4(5):523-32. doi: 10.1007/BF00869840.
10
A study by immunofluorescence microscopy of the NC1 domain of collagen type IV in glomerular basement membranes of two patients with hereditary nephritis.一项通过免疫荧光显微镜对两名遗传性肾炎患者肾小球基底膜中IV型胶原NC1结构域进行的研究。
Virchows Arch A Pathol Anat Histopathol. 1990;416(3):205-12. doi: 10.1007/BF01678979.