Di Colo G, Manzi S, Nannipieri E
Farmaco Sci. 1981 Aug;36(8):692-704.
The in vitro methods for studying the intestinal absorption of drugs involving the use of the isolated rat small intestine are reviewed in order to provide indications on their actual usefulness and limitations. The most significant works dealing with the structural integrity of the intestinal mucosa, the functional integrity of the isolated intestine, the factors influencing passive transport such as pH, sugars, ions, physiological and synthetic surface-active agents, and complexation, are reviewed.
本文综述了利用离体大鼠小肠研究药物肠道吸收的体外方法，以说明其实际效用和局限性。文中回顾了关于肠黏膜结构完整性、离体肠功能完整性、影响被动转运的因素（如pH值、糖类、离子、生理和合成表面活性剂以及络合作用）的最重要研究成果。
