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Incidence and mechanisms of adverse reactions to polypeptides in man and dog.

作者信息

Lorenz W, Doenicke A, Schöning B, Karges H, Schmal A

出版信息

Dev Biol Stand. 1980;48:207-34.

PMID:7024019
Abstract

Adverse reactions (pseudoallergic = anaphylactoid (severe) and allergoid (slight)) to polygeline (Haemaccel) are caused by histamine release. The mechanism by which other polypeptides produce these reactions is unfortunately hitherto unknown. "Purification" of Haemaccel led to a drug which was free from anaphylactoid reactions in a controlled clinical trial. Clinically insignificant allergoid reactions to polygeline (restricted to the skin) could be prevented by premedication with H1 + H2-receptor antagonists.

摘要

相似文献

1
Incidence and mechanisms of adverse reactions to polypeptides in man and dog.
Dev Biol Stand. 1980;48:207-34.
2
Prevention of allergoid (cutaneous anaphylactoid) reactions to polygeline (Haemaccel) in orthopaedic patients by premedication with H1- and H2-receptor antagonists.
Dev Biol Stand. 1980;48:241-9.
3
[Anaphylactoid reactions following administration of plasma substitutes in man. Prevention of this side-effect of haemaccel by premedication with H1- and H2-receptor antagonists (author's transl)].[人体输注血浆代用品后的类过敏反应。用H1和H2受体拮抗剂进行预处理预防贺斯（Haemaccel）的这种副作用（作者译）]
Anaesthesist. 1977 Dec;26(12):644-8.
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H1 + H2-receptor antagonists for premedication in anaesthesia and surgery: a critical view based on randomized clinical trials with Haemaccel and various antiallergic drugs.用于麻醉和手术术前用药的H1+H2受体拮抗剂：基于使用贺斯（Haemaccel）和各种抗过敏药物的随机临床试验的批判性观点
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Prophylaxis of anaphylactoid reactions to a polypeptidal plasma substitute by H1- plus H2-receptor antagonists: synopsis of three randomized controlled trials.H1 加 H2 受体拮抗剂预防对多肽类血浆代用品的类过敏反应：三项随机对照试验的综述
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[Haemaccel 35: adverse reactions in a multicentric, prospective study].[血代35：一项多中心前瞻性研究中的不良反应]
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Reactions to Haemaccel.
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Prediction of risk for pseudoallergic reactions and histamine release in patients undergoing anaesthesia and surgery: a computer-aided model using independence-Bayes.
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引用本文的文献

1
Prophylaxis of anaphylactoid reactions to a polypeptidal plasma substitute by H1- plus H2-receptor antagonists: synopsis of three randomized controlled trials.H1 加 H2 受体拮抗剂预防对多肽类血浆代用品的类过敏反应：三项随机对照试验的综述
Klin Wochenschr. 1982 Sep 1;60(17):1048-55. doi: 10.1007/BF01716970.
2
Histamine release in anaesthesia and surgery. premedication with H1- and H2-receptor antagonists: indications, benefits and possible problems.
Klin Wochenschr. 1982 Sep 1;60(17):1039-45. doi: 10.1007/BF01716968.