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移植血红蛋白类型改变的骨髓细胞。

Transplantation of bone marrow cells with changed haemoglobin type.

作者信息

Sulc K, Kobylka P, Neuwirt J, Trávnícek T

出版信息

Haematologia (Budap). 1981;14(2):159-64.

PMID:7024054
Abstract

Haemoglobin was used as a marker for the detection of radiation chimera in rats. After a single blood loss, the synthesis of haemoglobin type had changed, as observed in peripheral blood one week after bleeding. After one month the haemoglobin pattern was the same in the experimental rats and in the control animals. Twenty-four hours before bone marrow transplantation the donors were bled. Haemoglobin synthesis had changed also in the recipients. In contrast with a single blood loss, this change of haemoglobin type persisted as observed one year after transplantation. The cells with changed synthesis can repeatedly be retransplanted.

摘要

血红蛋白被用作检测大鼠辐射嵌合体的标志物。单次失血后,血红蛋白类型的合成发生了变化,这在失血一周后的外周血中可以观察到。一个月后,实验大鼠和对照动物的血红蛋白模式相同。在骨髓移植前24小时,对供体进行放血。受体的血红蛋白合成也发生了变化。与单次失血不同,这种血红蛋白类型的变化在移植后一年仍持续存在。合成发生变化的细胞可以反复进行再移植。

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