Nekrasova A A
Kardiologiia. 1981 Jul;21(7):13-20.
The author studied the renin-angiotensin, and kallikrein-kinin systems and renal prostaglandins in patients with different stages of hypertension. The activity of plasma renin and the content to PG in the peripheral blood and the blood from the renal veins, PGE2 excretion, PGG2 and kallikrein in the urine have been studied. Overloads have been used, directed at the activation of the sympathetic nervous system. It is concluded that a functional rearrangement of the endocrine renal function exists in patients with the hypertensive disease, which is related to the development of defects in the control of one series of the humoral systems and to the compensatory changes in the others. The increase of extracellular volume is the reason of the functional endocrine changes in the kidney, which is shown by the results of studies after salt overloads.
作者研究了不同阶段高血压患者的肾素 - 血管紧张素系统、激肽释放酶 - 激肽系统以及肾脏前列腺素。对血浆肾素活性、外周血和肾静脉血中前列腺素的含量、尿中PGE2排泄量、PGG2和激肽释放酶进行了研究。采用了旨在激活交感神经系统的负荷试验。得出的结论是，高血压病患者存在肾脏内分泌功能的功能性重排，这与一系列体液系统控制缺陷的发展以及其他系统的代偿性变化有关。细胞外液量的增加是肾脏功能性内分泌变化的原因，盐负荷试验后的研究结果表明了这一点。
