Davie J R, Saunders C A, Walsh J M, Weber S C
Nucleic Acids Res. 1981 Jul 10;9(13):3205-16. doi: 10.1093/nar/9.13.3205.
The content of the acetylated histone species associated with the highly transcriptionally active chromatin of yeast was examined. We found yeast chromatin to contain very high levels of the acetylated species for histones H3, H4 and possibly the H2B variants, H2B-1 and H2B-2. Sixty-three percent of the histone H4 species was represented by the di-, tri- and tetra-acetylated forms. These results make yeast chromatin among the most highly acetylated of any chromatins reported thus far. In addition, the results are consistent with the idea that hyperacetylation of histones allows chromatin to be transcribed at an increased rate.
对与酵母高度转录活性染色质相关的乙酰化组蛋白种类的含量进行了检测。我们发现酵母染色质中组蛋白H3、H4以及可能的H2B变体H2B - 1和H2B - 2的乙酰化种类水平非常高。组蛋白H4种类的63%由二乙酰化、三乙酰化和四乙酰化形式代表。这些结果使酵母染色质成为迄今为止报道的所有染色质中乙酰化程度最高的之一。此外，这些结果与组蛋白高度乙酰化能使染色质以更高速率转录的观点一致。
