Kretchman J M, Rogers B S
Am J Med Technol. 1981 Jul;47(7):561-6.
Calcium accumulation in erythrocytes leads to a disco-spheroechinocyte shape transformation with a loss of cellular deformability resulting in a decreased lifespan in the peripheral circulation. This review discusses the role of calcium in the morphologic alteration of erythrocytes which appears to involve modifications of the inner membrane cytoskeletal proteins that regulate cell shape and membrane deformability. It is hypothesized that calcium interacts with the cytoskeletal proteins to alter their physical state or spatial arrangement such that there is a contractile response of the internal lipid bilayer which causes the echinocytic shape.
红细胞中的钙积累会导致细胞形状转变为盘状棘红细胞，同时细胞变形能力丧失，致使在外周循环中的寿命缩短。本综述讨论了钙在红细胞形态改变中的作用，这似乎涉及调节细胞形状和膜变形能力的内膜细胞骨架蛋白的修饰。据推测，钙与细胞骨架蛋白相互作用，改变其物理状态或空间排列，从而使内部脂质双层产生收缩反应，导致棘红细胞形状的出现。
