Pryjma J, Godzińska E
Arch Immunol Ther Exp (Warsz). 1981;29(1):35-42.
The humoral immune response to T-dependent antigens (SRBC, DNP5BSA, DNP50BSA, DNP-KLH) and T-independent antigens (SIII, Levan, DNP-SIII, DNP-Levan) was studied by hemolytic plaque assay in mice depleted of C3 by Cobra venom treatment. Suppression of the immune response in C3 depleted animals was not restricted only to T-dependent response and also the response to some T-dependent antigens (DNP50-BSA, DNP-KLH) was not suppressed under conditions of the experiment. Results are discussed in relation to postulated exclusive role of C3 in the induction of T-dependent immune response.
通过溶血空斑试验，在经眼镜蛇毒处理而使C3耗竭的小鼠中，研究了对T细胞依赖性抗原（绵羊红细胞、二硝基苯-5-牛血清白蛋白、二硝基苯-50-牛血清白蛋白、二硝基苯-钥孔戚血蓝蛋白）和T细胞非依赖性抗原（III型肺炎球菌多糖、左聚糖、二硝基苯-III型肺炎球菌多糖、二硝基苯-左聚糖）的体液免疫反应。C3耗竭动物中免疫反应的抑制不仅限于T细胞依赖性反应，而且在实验条件下，对某些T细胞依赖性抗原（二硝基苯-50-牛血清白蛋白、二硝基苯-钥孔戚血蓝蛋白）的反应也未受到抑制。结合C3在诱导T细胞依赖性免疫反应中假定的独特作用对结果进行了讨论。
