Breathnach S M, Bhogal B, Dyck R F, De Beer F C, Black M M, Pepys M B
Br J Dermatol. 1981 Aug;105(2):115-24. doi: 10.1111/j.1365-2133.1981.tb01195.x.
The presence of amyloid P component (AP) in dermal deposits of cutaneous amyloidosis was demonstrated by a direct immunofluorescence technique using an antibody to serum amyloid P component (SAP). AP was also shown, for the first time, to be a constituent of normal human skin. It was present at the periphery of dermal elastic tissue fibres, in basement membranes of dermal blood vessels and surrounding eccrine sweat glands but was absent from the dermo-epidermal basement membrane. The staining pattern in cutaneous amyloidosis was morphologically distinctive and readily distinguishable from staining of thickened vascular basement membranes in porphyria. Immunofluorescence with anti-SAP is simple and specific and may become the procedure of choice in the differential diagnosis of amyloidosis.
采用抗血清淀粉样蛋白P成分（SAP）抗体的直接免疫荧光技术，证实了皮肤淀粉样变性的皮肤沉积物中存在淀粉样蛋白P成分（AP）。首次表明，AP也是正常人皮肤的一种成分。它存在于真皮弹性组织纤维的周边、真皮血管的基底膜以及周围的外分泌汗腺中，但在真皮-表皮基底膜中不存在。皮肤淀粉样变性的染色模式在形态上具有独特性，很容易与卟啉病中增厚的血管基底膜染色区分开来。抗SAP免疫荧光简单且特异，可能会成为淀粉样变性鉴别诊断的首选方法。
