Hagenfeldt K, Bygdeman M
Reproduccion. 1981 Jul-Sep;5(3):195-201.
The development of generally applicable, simple non-surgical methods for menstrual regulation has been desired for a long time. Such an approach to fertility control depends on the availability of a suitable therapeutic agent that should be effective, reliable, simple to administer and free from disturbing side effects. The classical prostaglandins have shown the capability but are unsuitable mainly due to high incidence of side effects. Most of these drawbacks seem to be overcome when prostaglandin analogues are used; however, vaginal administration caused appreciable pain in 10-30% of women, and so severely limits self-administration of these analogues.
长期以来，人们一直期望开发出普遍适用、简单的非手术月经调节方法。这种控制生育的方法取决于是否有合适的治疗药物，该药物应有效、可靠、易于给药且无不良副作用。经典前列腺素已显示出这种能力，但主要由于副作用发生率高而不适用。使用前列腺素类似物时，这些缺点大多似乎可以克服；然而，10%至30%的女性在阴道给药时会感到明显疼痛，因此严重限制了这些类似物的自我给药。
