Fujimoto K, Sakaguchi T, Ui M
Diabetologia. 1981 May;20(5):568-72. doi: 10.1007/BF00252767.
Simultaneous occurrence of hyperglycaemia (up to 300 mg/100 ml) and hyperinsulinaemia (up to 1200 mu U/ml) was evident in the fed state in genetically diabetic KK mice, indicating insulin resistance. The hyperinsulinaemia was enhanced by alpha-adrenergic blockade and alleviated by B-blockade. Epinephrine-induced hyperglycaemia and isoproterenol-induced hyperinsulinaemia, both of which could be blocked by beta-adrenergic antagonists, were more marked in KK mice than in ICR mice. A possible significance of adrenergic mechanisms is discussed with respect to the aetiology of the metabolic disturbances characteristic of KK mice.
在遗传性糖尿病KK小鼠的进食状态下，明显同时出现高血糖（高达300mg/100ml）和高胰岛素血症（高达1200μU/ml），这表明存在胰岛素抵抗。α-肾上腺素能阻断可增强高胰岛素血症，而β-阻断则可减轻高胰岛素血症。肾上腺素诱导的高血糖和异丙肾上腺素诱导的高胰岛素血症在KK小鼠中比在ICR小鼠中更明显，两者均可被β-肾上腺素能拮抗剂阻断。本文讨论了肾上腺素能机制在KK小鼠特征性代谢紊乱病因学方面的可能意义。
