Klepp O, Klepp R, Host H, Asbjornsen G, Talle K, Stenwig A E
Cancer. 1977 Aug;40(2):638-46. doi: 10.1002/1097-0142(197708)40:2<638::aid-cncr2820400208>3.0.co;2-6.
Forty-three patients with disseminated germ cell cancer were treated with a combination of vincristine, Adriamycin, cyclophosphamide, actinomycin-D, and medroxyprogesterone acetate. All the 43 patients were considered evaluable for response. Thirty-one patients (72%) achieved a complete or partial remission and 14 (32.5%) achieved a complete remission. The patients who attained an objective response obtained a significant prolongation of life compared with the nonresponders (median survival 55 vs. 23 weeks). Responses were seen in all histologic categories and most frequently in patients with metastases confined to the lungs. The major side effects were leukopenia and stomatitis. There were no deaths related to toxicity of the chemotherapy.
43例播散性生殖细胞癌患者接受了长春新碱、阿霉素、环磷酰胺、放线菌素-D和醋酸甲羟孕酮联合治疗。所有43例患者均被认为可评估疗效。31例患者（72%）达到完全或部分缓解，14例（32.5%）达到完全缓解。与无反应者相比，获得客观反应的患者生存期显著延长（中位生存期55周对23周）。所有组织学类型均可见反应，最常见于转移局限于肺部的患者。主要副作用为白细胞减少和口腔炎。没有与化疗毒性相关的死亡病例。
