Buchanan G R, Handin R I
JAMA. 1978 Nov 10;240(20):2173-4.
Twenty-three patients with severe hemophilia were given single or multiple doses of diphenhydramine hydrochloride, chlorpromazine hydrochloride, or guaifenesin to test their effects on hemostasis. In contrast with earlier studies with aspirin, bleeding times were not prolonged after ingestion of these three drugs. No patient had hemorrhage because of the drugs, and none recalled excessive bleeding following drug ingestion. These results greatly extend the clinical implications of prior observations carried out in normal subjects demonstrating that many antiplatelet drugs have no effects on in vivo hemostasis. We conclude that these drugs are probably safe for patients with bleeding disorders like hemophilia.
对23名重度血友病患者给予单剂量或多剂量的盐酸苯海拉明、盐酸氯丙嗪或愈创甘油醚，以测试它们对止血的影响。与早期使用阿司匹林的研究不同，摄入这三种药物后出血时间并未延长。没有患者因这些药物而出血，也没有患者回忆起服药后有过度出血的情况。这些结果极大地扩展了之前在正常受试者中进行的观察结果的临床意义，表明许多抗血小板药物对体内止血没有影响。我们得出结论，这些药物对血友病等出血性疾病患者可能是安全的。
