Gross M, Bush H, McTigue H, Hamburger R J, Flamenbaum W
Prostaglandins. 1981 Jun;21(6):879-88. doi: 10.1016/0090-6980(81)90157-x.
A comparison of the efficacy of prostacyclin and heparin as anticoagulants during hemodialysis in uremic dogs was evaluated. Prostacyclin was infused continuously into the arterial limb of the dialyzer (100 ng/kg/min) while heparin was administered as a 5000 unit bolus at the beginning of dialysis. Prostacyclin and heparin were alternated and a total of 4 dialyses/dog were performed. Parameters followed to assess the efficacy of dialyses included: dialysance (ml/min) of urea, creatinine, ultrafiltration rate (ml/hr), residual volume and platelet count (% of baseline). A lesser degree of hemodialysis associated thrombocytopenia, and a higher ultrafiltration rate were observed with prostacyclin. These studies demonstrate that prostacyclin can be used alone as an anticoagulant in a uremic dog model, and in contrast to heparin it maintains the platelet count and improves the ultrafiltration rate during hemodialysis.
对前列腺素和肝素在尿毒症犬血液透析期间作为抗凝剂的疗效进行了比较评估。前列腺素持续输注到透析器的动脉端（100 ng/kg/分钟），而肝素在透析开始时作为5000单位的推注给药。前列腺素和肝素交替使用，每只犬共进行4次透析。用于评估透析效果的参数包括：尿素、肌酐的透析率（毫升/分钟）、超滤率（毫升/小时）、残余容积和血小板计数（基线的百分比）。使用前列腺素时观察到血液透析相关血小板减少程度较轻，超滤率较高。这些研究表明，在尿毒症犬模型中，前列腺素可单独用作抗凝剂，与肝素不同的是，它在血液透析期间能维持血小板计数并提高超滤率。
