Perticoni G F, Pezzella F, Ferroni A
Riv Patol Nerv Ment. 1980 Mar-Apr;101(2):51-66.
The clinical data are presented of 11 subjects affected by a sporadic form of Parkinsonism with associated motor neuron disease. Combined lesions of upper and lower neuron were found in 10 of 11 cases, while in the remaining case only lower motor neuron disorder was present. The female/man ratio is 1/11. The early symptoms appear at a mean age of 56.9 years: in 6 patients with both syndromes at the same time while in 4 only with Parkinson. These observations confirm the view that different degenerative neurological syndromes must not be considered autonomous entities, but only different forms of polysystemic degenerative diseases that choose, in particular conditions, some neuronal districts rather than others.
本文呈现了11例散发性帕金森综合征合并运动神经元病患者的临床资料。11例中有10例发现上下运动神经元联合病变，其余1例仅存在下运动神经元障碍。女性/男性比例为1/11。早期症状出现的平均年龄为56.9岁：6例患者同时出现两种综合征，4例仅患有帕金森病。这些观察结果证实了这样一种观点，即不同的退行性神经综合征不应被视为独立的实体，而只是多系统退行性疾病的不同形式，在特定条件下，这些疾病会选择某些神经元区域而非其他区域。
