Roos J C, Dorhout Mees E J, Koomans H A, Geyskes G G, Boer P
Acta Med Scand. 1981;210(1-2):79-84. doi: 10.1111/j.0954-6820.1981.tb09779.x.
The effect of 50 mg chlorthalidone on blood pressure, body fluid volumes and renal functional parameters was determined in 8 patients with essential hypertension. After 3 days there were signs of volume depletion with little change in mean arterial pressure (MAP). Maximal free water clearance (CH2O) was decreased and fractional proximal sodium reabsorption was increased, but no correlations between these parameters were found. After 3 months there was in inverse relationship between both changes in MAP and the indices of volume depletion and CH2O. It is concluded that when MAP decreases after prolonged saluretic treatment, there is a partial recovery of the initially induced volume depletion and less stimulation of proximal tubular sodium reabsorption. The continuing inhibitory action of chlorthalidone on "distal" sodium reabsorption is partially compensated for, probably by the stimulating effect at this site of the decrease in MAP.
在8例原发性高血压患者中测定了50毫克氯噻酮对血压、体液容量和肾功能参数的影响。3天后出现容量耗竭迹象，平均动脉压（MAP）变化不大。最大自由水清除率（CH2O）降低，近端钠重吸收分数增加，但未发现这些参数之间存在相关性。3个月后，MAP变化与容量耗竭指标及CH2O之间呈负相关。得出的结论是，在长期使用利尿药治疗后MAP下降时，最初诱发的容量耗竭会部分恢复，近端肾小管钠重吸收的刺激减少。氯噻酮对“远端”钠重吸收的持续抑制作用可能部分被MAP降低对该部位的刺激作用所补偿。
