Lameyer L D, Hesse C J
Ann Clin Res. 1981;13 Suppl 30:16-22.
The effects of two beta-adrenoceptor blockers, the beta1-selective metoprolol and the non-selective propranolol, was studied in high renin patients (n = 15) with very high pretreatment blood pressures. Ten of the patients had essential hypertension and five renal artery stenosis. From high blood pressure values after six weeks on placebo, there was a pronounced drop in both supine and standing blood pressures in both groups with a small to moderate dose of beta-blocker, thus showing that the good blood pressure control in high renin patients is not connected to blockade of beta2-receptors or to the aetiology of the hypertension. In patients with essential hypertension who were treated with metoprolol, a significant positive correlation (r = 0.66, n = 10) was also found between the fall in blood pressure and the fall in plasma renin activity. Values for glomerular filtration rate (GFR) before and after treatment were unchanged throughout the whole spectrum of GFR from those values indicating substantially decreased kidney function up to normal values.
在高血压前期血压非常高的高肾素患者（n = 15）中，研究了两种β-肾上腺素受体阻滞剂（β1选择性美托洛尔和非选择性普萘洛尔）的效果。其中10名患者患有原发性高血压，5名患者患有肾动脉狭窄。与服用安慰剂六周后的高血压值相比，两组患者在使用小至中等剂量β受体阻滞剂后，仰卧位和站立位血压均有明显下降，这表明高肾素患者良好的血压控制与β2受体阻滞或高血压的病因无关。在用美托洛尔治疗的原发性高血压患者中，还发现血压下降与血浆肾素活性下降之间存在显著正相关（r = 0.66，n = 10）。从表明肾功能大幅下降到正常的整个肾小球滤过率（GFR）范围内，治疗前后的GFR值均未改变。
