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[关于甲型和乙型病毒性肝炎在意大利都灵传播情况的血清流行病学研究(作者译)]

[Sero-epidemiological studies on diffusion of viral hepatitis "A" and "B" in Turin (Italy) (author's transl)].

作者信息

Giuliani G, Varetti G, Paggi G C, Frezet D

出版信息

Ann Sclavo. 1981 Jan-Feb;23(1):33-43.

PMID:7027979
Abstract

The age-prevalence of antibodies directed against the hepatitis viruses A (anti-HAV) and B (anti-HBs and anti-HBc) has been studied in an open sample of population of Turin (Italy), made up by 680 persons. Is has been shown that all three types of antibodies are present at birth, thast they progressively decrease and than again raise, from 6-10 years of age, up to 70-75%, 35% and about 40% in adults, respectively for anti-HAV, anti-HBs and anti-HBc. A further peak over 97% after 40 years for anti-HAV likely means a past higher spreading of the virus. The conclusion is drawn that, for both hepatitis A and B, the percentage of positive and the time of appearance of active humoral immunity after the loss of maternal antibodies are typical medium level of hygienic conditions. The comparison of anti-HBs and anti-HBc behaviour has shown that the latter is more frequent and at least as persistent as the former, and that it should not therefore be obligatory considered ia a marker of viral replication.

摘要

在意大利都灵的一个由680人组成的开放性人群样本中,研究了针对甲型肝炎病毒(抗-HAV)和乙型肝炎病毒(抗-HBs和抗-HBc)的抗体年龄患病率。结果表明,这三种抗体在出生时均存在,随后逐渐下降,然后从6至10岁开始再次上升,在成年人中,抗-HAV、抗-HBs和抗-HBc的阳性率分别高达70 - 75%、35%和约40%。40岁以后抗-HAV超过97%的另一个峰值可能意味着该病毒过去有更高的传播率。得出的结论是,对于甲型和乙型肝炎,在母体抗体消失后,阳性百分比和主动体液免疫出现的时间是卫生条件的典型中等水平。抗-HBs和抗-HBc行为的比较表明,后者更常见,并且至少与前者一样持久,因此不应将其必然视为病毒复制的标志物。

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