通过与编码前体的克隆胰岛cDNA杂交鉴定出的肠胰高血糖素mRNA。 - Suppr | 超能文献

Intestinal glucagon mRNA identified by hybridization to a cloned islet cDNA encoding a precursor.

作者信息

Lund P K, Goodman R H, Habener J F

出版信息

Biochem Biophys Res Commun. 1981 Jun;100(4):1659-66. doi: 10.1016/0006-291x(81)90709-9.

DOI:10.1016/0006-291x(81)90709-9

Abstract

摘要

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Intestinal glucagon mRNA identified by hybridization to a cloned islet cDNA encoding a precursor.通过与编码前体的克隆胰岛cDNA杂交鉴定出的肠胰高血糖素mRNA。

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2

Pancreatic pre-proglucagons are encoded by two separate mRNAs.胰高血糖素原前体由两种不同的mRNA编码。

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5

Molecular and cellular responses of islets during perturbations of glucose homeostasis determined by in situ hybridization histochemistry.通过原位杂交组织化学确定葡萄糖稳态扰动期间胰岛的分子和细胞反应。

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Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences.胰脏α细胞中胰高血糖素原的转化：主要终产物是胰高血糖素和一种单一肽段，即主要的胰高血糖素原片段，其包含两个胰高血糖素样序列。

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In-vitro biosynthesis of multiple preproglucagons results from acetylation of the primary translation products.多种前胰高血糖素原的体外生物合成源于初级翻译产物的乙酰化作用。

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Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription.Pax6在控制肠内分泌胰高血糖素原基因转录中的基本要求。

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Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor.源自转基因小鼠肿瘤的胰腺α样细胞系中胰高血糖素原的加工与正常胰岛相似。

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An emerging role of glucagon-like peptide-1 in preventing advanced-glycation-end-product-mediated damages in diabetes.胰高血糖素样肽-1在预防糖尿病晚期糖基化终产物介导的损伤中的新作用。

Mediators Inflamm. 2013;2013:591056. doi: 10.1155/2013/591056. Epub 2013 Jan 10.

2

Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic benefits beyond glycaemic control?胰高血糖素样肽-1 的新兴心血管作用：除血糖控制之外的潜在治疗益处？

Br J Pharmacol. 2009 Aug;157(8):1340-51. doi: 10.1111/j.1476-5381.2009.00376.x.

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Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem.胰高血糖素原前体 cDNA 包含两个串联排列的与胰高血糖素相关的编码序列。

Proc Natl Acad Sci U S A. 1982 Jan;79(2):345-9. doi: 10.1073/pnas.79.2.345.