心肌病中的心脏抗体。
Heart antibodies in cardiomyopathies.
作者信息
Trueman T, Thompson R A, Cummins P, Littler W A
出版信息
Br Heart J. 1981 Sep;46(3):296-301. doi: 10.1136/hrt.46.3.296.
The reported frequency of circulating heart reactive antibodies in cardiomyopathies has varied and their significance is unknown. In this study such antibodies were sought in patients with primary congestive and hypertrophic cardiomyopathies and other heart diseases. Standard "single sandwich" and the more sensitive "double sandwich" indirect immunofluorescence techniques failed to disclose a significant difference between any cardiomyopathic group and controls in repeated experiments. With both techniques results were subject to considerable method-specific artefacts and observer variation. No published work associating heart antibodies detected by immunofluorescence methods with cariomyopathies adequately takes these into account.
在心肌病中，循环性心脏反应性抗体的报告频率各不相同，其意义尚不清楚。在本研究中，对原发性充血性和肥厚性心肌病患者以及其他心脏病患者进行了此类抗体的检测。在重复实验中，标准的“单夹心”和更敏感的“双夹心”间接免疫荧光技术未能揭示任何心肌病组与对照组之间的显著差异。使用这两种技术，结果都受到相当大的方法特异性假象和观察者差异的影响。没有已发表的将通过免疫荧光方法检测到的心脏抗体与心肌病相关联的研究充分考虑到这些因素。
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