肺癌特异性主动免疫疗法的失败
Failure of specific active immunotherapy in lung cancer.
作者信息
Souter R G, Gill P G, Gunning A J, Morris P J
出版信息
Br J Cancer. 1981 Oct;44(4):496-501. doi: 10.1038/bjc.1981.217.
Abstract
A randomized trial comparing routine follow-up with a treatment regimen aimed at increasing specific anti-tumour immunity has been carried out in 95 patients after total surgical excision of lung cancer (not small-cell). Treatment consisted of inoculation with an autologous irradiated suspension of tumour cells combined with a small dose of C. parvum given intradermally during convalescence. Although treatment was associated with virtually no side effects, there has been no apparent benefit and input to the trial has now stopped.
摘要
一项针对95例非小细胞肺癌患者进行了手术全切后的随机试验，比较了常规随访与旨在增强特定抗肿瘤免疫力的治疗方案。治疗包括接种自体经辐照的肿瘤细胞悬液，并在康复期皮内注射小剂量短小棒状杆菌。尽管治疗几乎没有副作用，但未显示出明显益处，该试验现已停止招募患者。
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