Leung P C, Whitmoyer D I, Arendash G W, Sawyer C H
Brain Res. 1981 Dec 7;226(1-2):143-54. doi: 10.1016/0006-8993(81)91089-1.
In freely-moving female rats the effects of intraventricular infusion of norepinephrine (NE) on multiunit activity (MUA) were examined in the Diagonal Band of Broca (DBB), medial preoptic area (MPOA) and anterior hypothalamic area (AHA), regions containing neurons producing luteinizing hormone-releasing hormone (LHRH). NE was infused at a dosage known to depress plasma LH levels in ovariectomized (OVX) rats and elevate plasma LH concentrations in OVX-estrogen-progesterone-primed (EBP) animals. It was found that in adult OVX rats MUA in the brain areas listed above was almost invariably inhibited by NE (20 of 23 cases or 87%; the other three cases showed no change in electrical activity). However, after priming with estrogen and progesterone only about one-third of the OVX-EBP rats gave an inhibitory response, with another one-third showing no change in MUA and the final one-third of the cases actually giving an excitatory MUA response to NE--the DBB neurons being the most positive in the regard. Thus it appears that responsiveness of LHRH and/or adjacent neurons to the modulatory action of NE may itself be modulated by the influence of gonadal steroids.
在自由活动的雌性大鼠中，研究了脑室内注入去甲肾上腺素（NE）对布罗卡斜角带（DBB）、内侧视前区（MPOA）和下丘脑前区（AHA）多单位活动（MUA）的影响，这些区域含有产生促黄体生成素释放激素（LHRH）的神经元。以已知能降低去卵巢（OVX）大鼠血浆LH水平并提高去卵巢-雌激素-孕酮预处理（EBP）动物血浆LH浓度的剂量注入NE。结果发现，在成年OVX大鼠中，上述脑区的MUA几乎总是被NE抑制（23例中有20例，即87%；其他3例电活动无变化）。然而，在用雌激素和孕酮预处理后，只有约三分之一的OVX-EBP大鼠产生抑制反应，另有三分之一的大鼠MUA无变化，最后三分之一的大鼠实际上对NE产生兴奋性MUA反应——DBB神经元在这方面最为明显。因此，似乎LHRH和/或相邻神经元对NE调节作用的反应性本身可能受性腺类固醇的影响调节。
