Whitcomb C C, Cousar J B, Flint A, Crissman J D, Bartolucci A A, Durant J R, Gams R A, Collins R D, Byrne G E
Cancer. 1981 Dec 1;48(11):2464-74. doi: 10.1002/1097-0142(19811201)48:11<2464::aid-cncr2820481120>3.0.co;2-4.
Five pathologists reviewed histologic slides from 134 cases of histiocytic lymphoma and subclassified these cases using Lukes-Collins classification system. Of 98 morphologically subclassifiable cases, 85 were distributed among three categories, each presumed to represent a lymphoma of follicular center cell origin. The remaining 12 cases were classified among three additional categories. The cases within the three follicular center cell categories, considered collectively, had a significantly better survival than did the cases within the other three categories considered as a whole. The pathologists classified cases generally as being of a follicular center cell type with a high degree of reproducibility, but their individual classifications varied significantly with respect to more specific morphologic categories. Suboptimal quality of histologic sections was a significant factor contributing to problems in morphologic classification. Ancillary immunologic techniques may be required for definitive subclassification of large cell lymphomas.
五位病理学家对134例组织细胞淋巴瘤的组织学切片进行了检查，并使用卢克斯-柯林斯分类系统对这些病例进行了亚分类。在98例形态学上可亚分类的病例中，85例分布在三个类别中，每个类别被认为代表滤泡中心细胞起源的淋巴瘤。其余12例被归类到另外三个类别中。总体来看，三个滤泡中心细胞类别中的病例的生存率明显高于另外三个类别整体的病例。病理学家对病例的分类通常高度一致地归为滤泡中心细胞类型，但他们在更具体的形态学类别方面的个人分类差异很大。组织学切片质量欠佳是导致形态学分类出现问题的一个重要因素。对于大细胞淋巴瘤的明确亚分类，可能需要辅助免疫技术。
